Progress on the EF-Hand Proteins
نویسندگان
چکیده
منابع مشابه
EF-hand calcium-binding proteins.
The EF-hand motif is the most common calcium-binding motif found in proteins. Several high-resolution structures containing different metal ions bound to EF-hand sites have given new insight into the modulation of their binding affinities. Recently determined structures of members of several newly identified protein families that contain the EF-hand motif in some of their domains, as well as of...
متن کاملPrediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins.
The EF-hand protein with a helix-loop-helix Ca(2+) binding motif constitutes one of the largest protein families and is involved in numerous biological processes. To facilitate the understanding of the role of Ca(2+) in biological systems using genomic information, we report, herein, our improvement on the pattern search method for the identification of EF-hand and EF-like Ca(2+)-binding protei...
متن کاملConformational control in EF-hand proteins
The ability to manipulate ligand-induced conformational change, although representing a major challenge to the protein engineer, is an essential end point in efforts to produce novel functional proteins for biotechnology and therapeutic applications. Progress towards this goal requires determining not only what factors control the fold and stability of a protein, but also how ligand binding alt...
متن کاملThe Neuronal Functions of EF-Hand Ca2+-Binding Proteins
that are not also CaM targets and this raises the question on the specificity and function of these interactions. Interestingly, binding of target proteins to NCS proteins and nCaBP has frequently different consequences than binding to CaM, which substantially increases the versatility of the Ca2+ signaling toolkit. The general idea of this special issue was to provide an overview on the functi...
متن کاملDetermination of the Membrane Topology of the Small EF-Hand Ca2+-Sensing Proteins CaBP7 and CaBP8
The CaBPs represent a subfamily of small EF-hand containing calcium (Ca(2+))-sensing proteins related to calmodulin that regulate key ion channels in the mammalian nervous system. In a recent bioinformatic analyses we determined that CaBP7 and CaBP8 form an evolutionarily distinct branch within the CaBPs (also known as the calneurons) a finding that is consistent with earlier observations chara...
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ژورنال
عنوان ژورنال: Biophysics
سال: 2013
ISSN: 2330-1686,2330-1694
DOI: 10.12677/biphy.2013.11001